Exploration of the Idea of Unblocking and Regulating the Dai Meridian as Main Intervention in Abdominal Obesity Metabolic Syndrome / 上海针灸杂志

Abdominal obesity is a core factor in and necessary condition of diagnosing metabolic syndrome. Abdominal fat contains two parts: subcutaneous fat and visceral fat. Both are related to hypertension, impaired fasting blood glucose, diabetes and metabolic syndrome. Current studies often focus on visceral fat, but subcutaneous fat accumulation also has an inseparable relationship. Physical and chemical changes in abdominal fat cells result in abdominal fat thickening and density increase and cause changes in secretion of adipokines in this process. The common action of the two aspects leads to a number of metabolic problems. The sanjiao dysfunction brings about abdominal accumulation of phlegm, heat and stagnant turbidity and infiltration of them into blood vessels, which are the basic pathogenesis of metabolic syndrome. Abnormal Dai Meridian function plays a key role in this process. Unblocking and regulating the Dai Meridian as a core means, promoting functional activities of qi in the whole body and especially in the middle jiao and restoring the sanjiao function help the clinical treatment of metabolic syndrome.

GluR2 expression in developing rat cochlear nucleus and relationship with development of synapse / 上海第二医科大学学报

Objective To investigate the trend of developmental expression of GluR2,subtype of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid(AMPA) receptor and synaptophysin(SYP) in the rat cochlear nucleus(CN) in different developmental stages,and explore the association of GluR2 expression with the development of synapse. Methods SD rats of 2,3,4,6,8 and 10 weeks old were selected,the expression of GluR2 and SYP in CN was detected with immunofluorescence histochemical method,and the association of them was explored. Results GluR2 expression was observed in all the neurons of CN in each postnatal groups.The expression was relatively weaker in the second and third week,became denser in the fourth week,reached the peak in the sixth week and then sharply decreased to the weakest in the tenth week.The expression of GluR2 was denser at granular cell layer,while weaker at molecular layer and multipolar cell layer in the dorsal CN.SYP expression was detected in all the neurons of CN in each postnatal groups.The expression was weakest in the second week,significantly denser in the fourth week,reached the peak in the sixth week,was then sharply decreased and stably maintained. Conclusion The expressions of GluR2 and SYP in the postnatal rat CN exhit an equally age-dependent tendency.The expression of GluR2 in the CN may be associated with the the maturation and function development of the CN.The different expression and distribution of GluR2 and SYP in the rat CN of different developmental stages may be involved in the development and plasticity of auditory center.